Targeted radiotherapy to the skeleton using 166Ho-DOTMP with autologous stem cell transplantation for patients with bone-only metastatic breast cancer
نویسندگان
چکیده
منابع مشابه
Autologous bone marrow transplantation for breast cancer.
There will be an estimated 180,000 new cases of breast cancer this year with 46,000 deaths. Adjuvant chemotherapy is now firmly established as a valuable modality in breast cancer, improving both disease-free and overall survival in appropriate patients. Unfortunately, chemotherapy has yielded little improvement in the survival of patients with metastatic breast cancer.
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Most patients relapse after high-dose chemotherapy (HDCT) with autologous stem-cell transplantation (ASCT) for metastatic breast cancer. Further chemotherapy immediately after hematopoietic recovery from ASCT is not given for fear of irreversibly damaging the newly engrafted stem cells. In a pilot chemoprotection trial, autologous CD34+ cells from patients with metastatic breast cancer were exp...
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Clinical trials of various procedures, including bone marrow stimulation, mosaicplasty, and autologous chondrocyte implantation, have been explored to treat articular cartilage defects. However, all of them have some demerits. We focused on autologous culture-expanded bone marrow mesenchymal stem cells (BMSC), which can proliferate without losing their capacity for differentiation. First, we tr...
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The prognosis is poor and the options are limited for patients with metastatic breast cancer (MBC), especially for those patients who have previously received taxanes and anthracyclines; treatment strategies are primarily palliative. Murine models have demonstrated that allogeneic T cells are capable of eliciting graft-versus-tumor (GVT) effects against breast cancer, inhibiting growth of breas...
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The treatment landscape for mantle cell lymphoma (MCL) is rapidly evolving toward the incorporation of novel and biologically targeted pharmaceuticals with improved disease activity and gentler toxicity profiles compared with conventional chemotherapeutics. Upfront intensive treatment of MCL includes autologous stem cell transplantation (SCT) consolidation aimed at deepening and lengthening dis...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2005
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2004.12.249